OPIOIDERGIC SYSTEM-MEDIATED ANTINOCICEPTIVE ACTIVITY OF TOFISOPAM

Objective: In this study, it was aimed to investigate the antinociceptive activity potential of Tofisopam and elucidate possible involvement opioid system in effect.Material Method: The efficacy (25 50 mg/kg) evaluated by hot-plate acetic acid-induced writhing tests; while effects drug on motor coordination mice were with Rota-rod tests.Result Discussion: at a dose mg/kg significantly prolonged reaction times tests reduced number behaviors tests. These findings indicated that has mediated central peripheral mechanisms. did not change activities mice. Pre-administration naloxone receptors effect abolished Tofisopam. To receptor subtypes mediating effect, mechanistic studies carried out naloxonazine (μ-opioid blocker), naltrindole (δ-opioid blocker) nor-binaltorphimine (ҡ-opioid blocker). All agents antagonized Obtained revealed have μ-, δ- ҡ-oipiod receptors.